Welcome to the Kinexus Web Site
Celebrating Over a Decade of Innovation and Exploration
Over 1600 laboratories in over 35 countries have benefited from our highly integrated platform of proteomics and bioinformatics services. Our unique services are convenient, cost-effective, insightful and enabling for identification and validation of biomarkers, drug targets and therapeutic compounds. Put our discovery engine to work for you.
What's New
Kinexus is pleased to introduce our starting line of well characterized antibodies and protein kinase substrate peptides. Many of these peptides have been designed with Kinexus’ proprietary prediction algorithms and individually tested against over 200 different human recombinant protein kinases to reveal the best. Check our Products webpages to determine the most potent and specific substrate peptides for your favorite protein kinase. Over the coming months, we will be adding more antibodies and substrate peptides for assaying diverse signalling proteins. In addition, we shall shortly be offering affordable do-it-yourself kits with our unique Kinex™ 800 antibody microarrays. Contact us if you can’t wait until their official product launch.
We have made several recent enhancements to our unique Kinex™ Antibody Microarray Services. Here are just nine of the reasons why you should try this powerful and affordable discovery strategy now.
- Convenience - Just send us your frozen biological specimens by courier.
- High Sensitivity - No sample enrichment required. Uses 100 µg of crude cell or tissue lysate protein.
- Wide Coverage - Tracks hundreds of cell signalling proteins with over 800 in-house validated, commercial antibodies (~540 pan-specific and ~270 phosphosite-specific).
- Reduced False Positives – Proprietary chemical cleavage of sample proteins lowers the risk of false positives from protein-protein interactions.
- Improved Surface Chemistry and Printing - With capture antibodies now printed with better morphology and consistency on 3D matrix-coated glass slides and improved signal-to-noise ratios (a dynamic signal detection range over 3 orders of magnitude).
- Single Dye, Non-competitive Methodology - Two samples are labelled with the same dye and incubated separately on the same slide to eliminate differential protein-dye binding problems.
- High Reproducibility - Duplicate measurements provided in detailed MS-Excel reports with further data analyses. Median error range of ~8%.
- Inexpensive Validation – Service available to confirm top18 hits from antibody microarray by immunoblotting. Additional enabling, follow up services are also available.
- Well Tested and Proven - Over 4000 antibody microarray analyses performed to date. Open access to full experimental data from over 2000 analyses available online for comparisons. Over 70 scientific peer-reviewed papers published using our antibody microarrays.
Our free online TranscriptoNET KnowledgeBase was generated from over 125 million measurements of the expression of over 21,000 human genes monitored with over 6000 gene microarrays deposited in the NCBI GEO database. TranscriptoNET can be queried to identify the most commonly, uniquely and highly expressed genes in over 300 human organs, tissues and cells as well as 300 established human tumour cell lines. It identifies those genes that are the most up-regulated and down-regulated in over 50 types of human cancers. It can also be used to identify the co-expression of genes, and similarities in gene expression between organs, tissues and cells.
Our free online PhosphoNET KnowledgeBase features detailed information on nearly 93,000 known and over 560,000 predicted phosphorylation sites in over 23,000 human proteins, including their evolutionary analysis in over 20 other species. Our proprietary Kinase Predictor algorithm has also identified the top 10% of 492 human protein kinases that best match each of these known and putative human phosphosites in PhosphoNET.
Direct Links to Free Kinexus Databases and Knowledgebases
