This page requires Adobe Flash Player to display correctly.
This ticker requires Adobe Flash Player to display correctly.

Kinexus Services Map

Kinase Inhibitor Customer Info Package IKPT Customer Info Package Peptide Synthesis Customer Info Package Peptide Array Customer Info Package KKSM_Kinase Substrate Array Customer Info Package IPMP Customer Info Package IKSP Customer Info Package MSPS MS Protein Site ID Customer Info Package PIMS MS Protein ID Customer Info Package KRLM Lysate Array Customer Info Package Graphics Customer Info Package IHC Customer Info Package Kinetworks Customer Info Package Antibody Array Customer Info Package In Vivo Cell Culture Customer Info Package In Vivo Cell Culture Customer Info Package Kinase Inhibitor Service IKPT Service Peptide Synthesis Service Peptide Array Service KKSM_Kinase Substrate Array Service Phosphonet Website IPMP Service IKSP Service MSPS MS Protein Site ID Service PIMS MS Protein ID Service Graphics Service KRLM Lysate Array Service Kinetworks Service IHC Service Antibody Array Service In Vivo Cell Culture Service In Vivo Cell Culture Service

Click on button to open a webpage with more information

Click INFO PDF to download a Customer Info Package

Welcome to the Kinexus Web Site

Celebrating Over 16 Years of Innovation and Exploration

Over 1700 laboratories in over 35 countries have benefited from our highly integrated platform of proteomics and bioinformatics services. Our unique services are convenient, cost-effective, insightful and enabling for identification and validation of biomarkers, drug targets and therapeutic compounds. Put our discovery engine to work for you.

What's New

Release of Our Superior Generic Phosphotyrosine-specific Antibody PYK

Our PYK rabbit polyclonal antibody (AB-PG001) was developed in-house through a novel strategy to detect a wider range of physiological protein-tyrosine phosphosites with greater sensitivity and specificity than the most popular phosphotyrosine-specific mouse monoclonal antibodies on the market today branded PY20, PY100 and 4G10 (download a PDF presentation with comparisons). PYK is now available in a convenient 25 µg pack size at 1 mg/ml concentration for as little as $US 89.
Our Kinex™ Antibody Microarray Services now utilize our latest generation KAM-880 Antibody Microarray with 877 signal transduction protein antibodies. The Kinex™ KAM-880 Antibody Microarray is also available for sale as a stand alone product or with supporting reagents in kits. Not only does our Antibody Microarray Kit track a broader range of protein kinases and protein phosphatases than our competition, but it offers the best value, reliability and follow-up opportunities in the market today (see our Competitor Analysis).

Below are just some of the reasons why you should try this powerful and affordable discovery strategy now. Click here to download more information about our affordable do-it-yourself Kinex™ KAM-880 Antibody Microarray Kits.
  1. Convenience - Just send us your frozen biological specimens by courier.

  2. High Sensitivity - No sample enrichment required. Uses 50 µg of crude cell or tissue lysate protein. Dynamic range of detection is greater than 6,000-fold.

  3. Wide Coverage - Tracks hundreds of cell signalling proteins with over 877 in-house validated, commercial antibodies (~518 pan-specific and ~359 phosphosite-specific).

  4. Independently Validated Antibodies - Cherry-picked from over 6000 sourced from over 25 vendors with about a third developed by and available directly from Kinexus.

  5. Reduced False Positives – Optional proprietary chemical cleavage of sample proteins lowers the risk of false positives from protein-protein interactions.

  6. Improved Surface Chemistry and Printing - With capture antibodies now printed with better morphology and consistency on 3D matrix-coated glass slides.

  7. Single Dye, Non-competitive Methodology - Two samples are labelled with the same dye and incubated separately on the same slide to eliminate differential protein-dye binding problems.

  8. High Reproducibility - Duplicate measurements provided in detailed MS-Excel reports with further data analyses. Median error range of ~12%. Average of duplicate measurements of the same sample on different chips have a median error range of ~8%.

  9. Inexpensive ValidationKinetworks™ Immunoblotting Services available to confirm top18 hits from our antibody microarray. Additional enabling, follow-up services are also available.

  10. Well Tested - Over 4500 antibody microarray analyses performed to date. Open access in KiNET to full experimental data from over 2000 analyses available online for comparisons.

  11. Well Proven - Over 150 scientific peer-reviewed papers published using our antibody microarrays.

What's Coming Soon

Kinexus first introduced our starting line of well characterized antibodies and protein kinase substrate peptides about 2 years ago. Many of these peptides were designed with Kinexus’ proprietary prediction algorithms and individually tested against over 200 different human recombinant protein kinases to reveal the best. Since then, we have been working on the development of over 500 protein kinase and phosphatase substrate peptides and the production and validation of over 650 pan- and phosphosite-specific antibodies for these enzymes. Regularly check our website over the coming months to see the latest product releases or get on our e-mailing list to be stay informed about our services and products.

High Content Sandwich Antibody Microarrays

Kinexus has been developing sandwich antibody microarrays for the capture of hundreds of cellular signalling proteins so they can be interrogated for changes in protein phosphorylation and other covalent modifications as well as specific protein-protein interactions with adapter, scaffolding and chaperone proteins. The first of these new microarrays for tracking the tyrosine-specific and total phosphorylation status of over 500 signal transduction proteins in cell and tissue lysates will shortly be released for use in our proteomics services and kits.

SigNET Open Access KnowledgeBases

DrugKiNET (www.drugnet.ca) features information on over 850 experimental compounds that have been reported to inhibit protein kinases as well as prediction of the sensitivities of 500 human protein kinases to over 550 of these compounds. DrugKiNET provides a listing of the lowest reported IC50, Ki or Kd values reported for each kinase-compound pair as well as detailed information on the structures of these compounds and links to other informative websites. Over 105,000 kinase-drug pairs were used to train two different proprietary algorithms developed at Kinexus to identify Inhibitory Drug Residues (IDRs) in protein kinases that appear to be the most critical for drug recognition. DrugKiNET can help identify new kinase targets for existing drugs, which can be further tested with our In Vitro Kinase-Inhibitor Activity Profiling (KICP) Services.
PhosphoNET (www.phosphonet.ca) features detailed information on over 177,000 known and over 785,000 predicted phosphorylation sites in over 21,000 human proteins, including their evolutionary analysis in over 20 other species. Our proprietary Kinase Predictor algorithm has also identified the top 10% of 492 human protein kinase domains that best match each of these known and putative human phosphosites in PhosphoNET. Kinase-substrate predictions can be further tested with our In Vitro Kinase and Phosphopeptide Testing (IKPT) Services.

Direct Links to Free Kinexus Databases and Knowledgebases

Stacks Image 0
Stacks Image 1
Stacks Image 2
Stacks Image 3
Stacks Image 4330

Kinexus Products Map

Antibody List Peptide List KAM-880 Antibody Microarray Kit KAM-880 Product Customer Information Package

Download an overview presentation about the Kinexus proteomics services

Stacks Image 4

Size: 1.7Mb

Stacks Image 5

Size: 13Mb

Kinexus Tweets

Credits