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Kinexus Services Map

Kinase Inhibitor Customer Info Package IKPT Customer Info Package Peptide Synthesis Customer Info Package Peptide Array Customer Info Package KKSM_Kinase Substrate Array Customer Info Package IPMP Customer Info Package IKSP Customer Info Package MSPS MS Protein Site ID Customer Info Package PIMS MS Protein ID Customer Info Package KRLM Lysate Array Customer Info Package Graphics Customer Info Package IHC Customer Info Package Kinetworks Customer Info Package Antibody Array Customer Info Package In Vivo Cell Culture Customer Info Package In Vivo Cell Culture Customer Info Package Kinase Inhibitor Service IKPT Service Peptide Synthesis Service Peptide Array Service KKSM_Kinase Substrate Array Service Phosphonet Website IPMP Service IKSP Service MSPS MS Protein Site ID Service PIMS MS Protein ID Service Graphics Service KRLM Lysate Array Service Kinetworks Service IHC Service Antibody Array Service In Vivo Cell Culture Service In Vivo Cell Culture Service

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Welcome to the Kinexus Web Site

Celebrating Over a Decade of Innovation and Exploration

Over 1650 laboratories in over 35 countries have benefited from our highly integrated platform of proteomics and bioinformatics services. Our unique services are convenient, cost-effective, insightful and enabling for identification and validation of biomarkers, drug targets and therapeutic compounds. Put our discovery engine to work for you.

What's New

Dr. Steven Pelech, the president and chief scientific officer of Kinexus, will be giving a Workshop entitled "Oncoproteomics for Uncovering Cancer Biomarkers and Therapeutic Targets." This workshop will show users how the Kinexus suite of open-access bioinformatics websites can be used to accelerate biomarker, drug target and drug discovery. Click here for more general information about this OMICS Group Conference devoted to exploring current trends and advances in proteomics and bioinformatics.

Release of Our Superior Generic Phosphotyrosine-specific Antibody PYK

Our PYK rabbit polyclonal antibody (AB-PG001) was developed in-house through a novel strategy to detect a wider range of physiological protein-tyrosine phosphosites with greater sensitivity and specificity than the most popular phosphotyrosine-specific mouse monoclonal antibodies on the market today branded PY20, PY100 and 4G10 (download a PDF presentation with comparisons). PYK is now available in a convenient 25 µg pack size at 1 mg/ml concentration for as little as $US 89.
There has never been a better time to take advantage of our unique Kinex™ Antibody Microarray Services with further expansion of the number of different antibodies featured on the microarray. Our latest generation Kinex™ KAM-850 Antibody Microarray is also now available for sale as a stand alone product or with supporting reagents in kits. Not only does our Antibody Microarray Kit track a broader range of protein kinases and protein phosphatases than our competition, but it offers the best value, reliability and follow-up opportunities in the market today (see our Competitor Analysis).

Below are just some of the reasons why you should try this powerful and affordable discovery strategy now. Click here to download more information about our affordable do-it-yourself Kinex™ KAM-850 Antibody Microarray Kits.
  1. Convenience - Just send us your frozen biological specimens by courier.

  2. High Sensitivity - No sample enrichment required. Uses 50 µg of crude cell or tissue lysate protein.

  3. Wide Coverage - Tracks hundreds of cell signalling proteins with over 850 in-house validated, commercial antibodies (~517 pan-specific and ~337 phosphosite-specific).

  4. Independently Validated Antibodies - Cherry-picked from over 4600 sourced from over 25 vendors

  5. Reduced False Positives – Optional proprietary chemical cleavage of sample proteins lowers the risk of false positives from protein-protein interactions.

  6. Improved Surface Chemistry and Printing - With capture antibodies now printed with better morphology and consistency on 3D matrix-coated glass slides and improved signal-to-noise ratios (a dynamic signal detection range over 3 orders of magnitude).

  7. Single Dye, Non-competitive Methodology - Two samples are labelled with the same dye and incubated separately on the same slide to eliminate differential protein-dye binding problems.

  8. High Reproducibility - Duplicate measurements provided in detailed MS-Excel reports with further data analyses. Median error range of ~12%. Average of duplicate measurements of the same sample on different chips have a median error range of ~8%.

  9. Inexpensive ValidationKinetworks™ Immunoblotting Services available to confirm top18 hits from our antibody microarray. Additional enabling, follow-up services are also available.

  10. Well Tested - Over 4000 antibody microarray analyses performed to date. Open access in KiNET to full experimental data from over 2000 analyses available online for comparisons.

  11. Well Proven - Over 100 scientific peer-reviewed papers published using our antibody microarrays.
Kinexus is pleased to introduce our starting line of well characterized antibodies and protein kinase substrate peptides. Many of these peptides have been designed with Kinexus’ proprietary prediction algorithms and individually tested against over 200 different human recombinant protein kinases to reveal the best. Check our Products webpages to determine the most potent and specific substrate peptides for your favorite protein kinase. Over the coming months, we will be adding more antibodies and substrate peptides for assaying diverse signalling proteins.
Kinexus is pleased to announce the launch of our open-access DrugKiNET website with experimental information on over 850 compounds that have been reported to inhibit protein kinases as well as prediction of the sensitivities of 500 human protein kinases to over 550 of these compounds. DrugKiNET provides a listing of the lowest reported IC50, Ki or Kd values reported for each kinase-compound pair as well as detailed information on the structures of these compounds and links to other informative websites. Over 105,000 kinase-drug pairs were used to train two different proprietary algorithms developed at Kinexus to identify Inhibitory Drug Residues (IDRs) in protein kinases that appear to be the most critical for drug recognition. DrugKiNET can help identify new kinase targets for existing drugs, which can be further tested with our In Vitro Kinase-Inhibitor Activity Profiling (KICP) Services.
Our free online PhosphoNET KnowledgeBase features detailed information on over 177,000 known and over 785,000 predicted phosphorylation sites in over 23,000 human proteins, including their evolutionary analysis in over 20 other species. Our proprietary Kinase Predictor algorithm has also identified the top 10% of 492 human protein kinases that best match each of these known and putative human phosphosites in PhosphoNET.

Direct Links to Free Kinexus Databases and Knowledgebases

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Kinexus Products Map

Antibody List Peptide List KAM-850 Antibody Microarray Kit KAM-850 Product Customer Information Package

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