KINEX™ Microarrays
The Kinex™ Microarray Services for signal transduction protein profiling are convenient and extremely cost-effective solutions for the broad discovery of productive research leads and extensive characterization of specific proteins and kinase inhibitors. Kinexus utilizes chips that are printed with solid pins to create high density arrays with antibodies (antibody microarrays), cell/tissue lysates (reverse microarrays), and recombinant protein kinases (protein kinase microarrays). Our unique microarray services provides researchers with access to this powerful technology for application to their research programs without the need for special expertise and expensive equipment such as microarray scanners and quantification software. Our goal is to keep the costs for our Kinex™ services lower than if clients purchased custom microarrays and tried to perform these analyses in-house in their own laboratories. Furthermore, Kinexus provides a variety of follow up services so that our clients can rapidly validate and correlate their microarray results for their most exciting research leads.
The Kinex™ Antibody Microarray services allow for a rapid screening with 800 commercial antibodies for potential to detect proteins that are altered in their expression, phosphorylation or protein-protein interactions in lysates from cells and tissues in response to diverse experimental perturbations or pathological conditions. Our Standard Kinex™ Reverse Microarray services permit our clients to further characterize specific proteins that are shown to be altered in our Kinex™ Antibody Microarray or Kinetworks™ Multi-immunoblotting services in a wide variety of tissues of monkey, mouse, rat and frog origin as well as 12 different human tumour cell lines treated in time course and dose response studies with diverse hormones and drugs. With our Custom Kinex™ Reverse Microarray services, Kinexus can produce microarrays with cell and tissue lysates that are supplied by our clients for analysis. These services provide a powerful strategy for biomarker discovery and validation.
The recent addition of our Kinex™ Protein Kinase Microarray services offers a new, relatively inexpensive means to screen over 150 human protein kinases for the ability of up to three compounds to inhibit the binding of an ATP probe. The key results from these analyses can be confirmed with our Kinase-Inhibitor Activity Profiling services.
The recent addition of our Kinex™ Protein Kinase Microarray services offers a new, relatively inexpensive means to screen over 150 human protein kinases for the ability of up to three compounds to inhibit the binding of an ATP probe. The key results from these analyses can be confirmed with our Kinase-Inhibitor Activity Profiling services.
