Protein Animations

The animations provided on this website are copyrighted by Kinexus Bioinformatics Corporation, but permission is given for their free use for personal and teaching purposes.

Many of these animations were produced in collaboration with Cameron Bowyer. They can be viewed using Quicktime Player. Any inquiries about these animations should be directed to Dr. Steven Pelech at Kinexus Bioinformatics Corporation (Phone: 604.323.2547 ext.10; e-mail: spelech@kinexus.ca)
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Signal Transduction Proteins in Multimeric Complexes – Space Filling Models

These animations feature rotating 3D x-ray crystallographic structures of representative signalling proteins in complexes, which have been separately colourized to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation Title And Description

1A0N

Nfat, Fos and Jun DNA-binding domains bound to DNA
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1A02

Fyn tyrosine kinase SH3 domain complexed with a synthetic peptide P2L corresponding to residues 91-104 of the p85 subunit of phosphatidylinositol 3- kinase
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1A37

14-3-3 bound to Raf kinase Ser-259 phosphorylation site containing peptide
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1A6Q

Protein-serine/threonine phosphatase 2C (PP2C)
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1AMP

cAMP-dependent protein kinase (PKA) catalytic subunit complexed with inhibitor portion of PKI inhibitor
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1AXC

Proliferating cell nuclear antigen (PCNA) binding to p21 WAF CDK inhibitor
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1B17

Insulin A and B chains in a complex
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1BUH

Cyclin-dependent kinase 2 (CDK2) complex with cell cycle-regulatory protein Ckshs1
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1CS4

Adenylate Cyclase C1A and C2A domains complexed with Gs alpha subunit
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1CVS

Fibroblast growth factor 2 (FGF2) dimer - fibroblast growth factor receptor1 (FGFR1) complex
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1CXZ

RhoA complexed with the effector domain of the protein kinase PKN/PRK1
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1D0G

Death receptor 5 (DR5) extracellular domain bound to Apo2 ligand/Trail
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1E0A_2

Cdc42 complexed with the GTPase binding domain of p21-activated kinase (PAK)
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1E0O

Fibroblast growth factor 1 (FGF1) dimer - fibroblast growth factor receptor 2 (FGFR2) complex
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1EBA_2

Erythropoietin (Epo) receptor extracellular domain bound to Epo
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1EFN

HIV-1 Nef protein in complex with Arg- 96I mutant Fyn SH3 Domain
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1ES7

Bone morphogenetic protein (BMP) receptor Ia extracellular domain bound to BMP-2
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1F1J

Caspase-7 in complex with Acetyl-Asp- Glu-Val-Asp-Cho
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1FAP

FKBP12-rapamycin complex interacting with PI3K-related kinase FRAP fragment
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1FPR

SHP-1 tyrosine phosphatase catalytic domain and an in vitro peptide substrate Py469 derived from SHPS-1
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1FQ1

Cyclin-dependent kinase 2 (CDK2) complexed with KAP
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1G1F

Protein tyrosine phosphatase 1B (PTP1B) complexed with a tri- phosphorylated peptide (Rdi(Ptr) Etd(Ptr)(Ptr)Rk) from the insulin receptor kinase
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1G3N

p18(Ink4C)-cyclin-dependent kinase 6 - cyclin K ternary complex
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1G6R

Superagonist T cell antigen receptor (TCR)/major histochemistry complex (MHC)
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1GNG

Glycogen synthase kinase-3 (GSK3) complex with Frattide peptide
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1GOT

Trimeric G protein complex of alpha, beta and gamma subunits
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1H10

Pleckstrin homology domain of Protein Kinase B/Akt bound to Ins(1,3,4,5)- tetrakisphosphate
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1H9O

Phosphatidylinositol 3-kinase (PI3K), p85- subunit: C-terminal SH2 domain complexed with a Tyr-751 phosphorylation site containing peptide from the platelet-derived growth factor receptor
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1HE8

Ras G12V - Phosphatidylinositol 3- kinase (PI3K) complex
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1I51

Caspase-7 in complex with Xenopus inhibitor of apoptosis (XIAP)
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1IRU

Mammalian 20S proteasome complex
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1ITB

Interleukin-1 (IL1) type-1 receptor complexed with interleukin-1 beta
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1JSU

Cyclin-dependent kinase 2 (CDK2)/cyclin A complexed with p27 KIP1
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1JWH

Casein kinase 2 (CK2) holoenzyme alpha and beta subunit quaternary complex
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1KX3

Histones H2A, H2B, H3 and H4 with DNA in nucleosomes core complexes
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1KZ0

Protein farnesyltransferase complexed with farnesylated K- Ras4B peptide product and farnesyl diphosphate substrate bound simultaneously
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1LAR

LAR receptor tyrosine phosphatase tandem phosphatase domains
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1MF8

Calcineurin (PP2B)-calmodulin - cyclophilin-cyclosporin complex
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1N8Z

ErbB2 (HER2) receptor tyrosine kinase extracelleular domain complexed with herceptin monoclonal antibody Fab fragment
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1NT9

RNA polymerase 2 complex
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1NVV

Ras-GTP of the Ras-specific nucleotide exchange factor Sos
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1O6K

Protein kinase B/Akt kinase domain S474D complexed with glycogen synthase kinase 3 peptide and AMP-PnP
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1OWM

G protein coupled receptor kinase 2 (GRK2/BARK) complexed with G- beta/gamma subunits
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1P9M

Interleukin-6 (IL6) alpha/interleukin-6 beta receptorand interleukin-6
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1PNX

30S Ribosome RNA and protein complex
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1PNY

50S Ribosome RNA and protein complex
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1Q4K

Polo-like kinase 1 (PLK1) polo-box domain in a complex with a phospho- peptide
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1RQQ

Insulin receptor tyrosine kinase in a complex with the SH2 domain of adapter APS anda substrate inhibitor
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1SHC

Shc PTB domain complexed with a phosphopeptide from the TrkA receptor- tyrosine kinase
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1TUP

Tumor suppressor p53 complexed with DNA
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1WQ1

Ras complexed with Ras-GTPase activating protein (GAP)
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1WWW

Nerve growth factor in complex with domain 5 of the TrkA receptor-tyrosine kinase
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2NGR

Cdc42 bound to the active and catalytically compromised forms of the Cdc42-GTPase activating protein (GAP)
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CAM2

Calmodulin-dependent kinase 2 oligomer complexed with calmodulin (artistic composite - (CaMK2 catalytic domain represented with phosphorylase kinase catalytic domain)
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egfr

Epidermal growth factor (EGF) receptor- tyrosine kinase domain dimer shown with plasma membrane and extracellular EGF domain (artistic composite)
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Signal Transduction Proteins – Ribbon, Stick and Ball 3D Models

These animations feature rotating 3D x-ray crystallographic structures of cell signalling proteins with ribbon, stick and ball representation to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation Title And Description

1B39

Cyclin-dependent kinase 2 (CDK2) with Thr-160 phosphorylation site - ball model
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1D5R

PTEN phosphoinositide phosphatase - ribbon model
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1DM2

CDK2 complexed marine sponge inhibitor hymenialdisine - ball model
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1E0A

Cdc42 complexed with the GTPase binding domain of p21-activated kinase-alpha (PAKa) - stick model
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1E8Z

Phosphatidylinositol 3-kinase gamma (PI3Kg) p110 catalytic subunit bound with inhibitor staurosporin - ribbon
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1EBA

Erythropoietin (Epo) receptor extracellular domain bound to Epo - ball model
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1F3M

p21-activated kinase-alpha (PAKa) autoregulatory domaincomplexed with its catalytic domain - ball and ribbon model
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1FAO

1FAO
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1FMK

Src protein-tyrosine kinase with SH2, SH3, catalytic domain and C-terminus - wire model
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1FMK

Src protein-tyrosine kinase - ribbon model
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1FYN

Fyn protein-tyrosine kinase SH3 domain with proline-containing polypeptide from 3BP-2 - ball model
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1GRI

Growth factor bound protein 2 (Grb2) - ribbon model
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1IAN

p38 MAPK alpha - ball model
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1IR3

Insulin receptor-tyrosine kinase catalytic domain with peptide substrate - stick model
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1MCO

Immunoglobulin - ball model
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1NTS

DNA double helix - stick model
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1PTU

Protein-tyrosine phosphatase 1B complexed with a phosphotyrosine-containing hexapeptide - stick model
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1QB0

Cdc25B dual specificty phosphatase - ribbon model
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1QB3

Cyclin-dependent kinase regulatory subunit (Cks1) - ball model
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1QJA

14-3-3 zeta dimer complexed with Raf1 phosphorylated serine-containing peptide - stick and ball model
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1QMZ

Cyclin-dependent kinase 2 (CDK2) complexed with cyclin A - ribbon and ball model
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1RVD

H-Ras small G protein G12V constitutively active mutant - ribbon model
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1WQ1

Ras complexed with Ras-GTPase activating protein (GAP) - ribbon model
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1ZEH

Insulin - ball model
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2CSN

Casein kinase 1 (CK1) catalytic subunit - ribbon model
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2HNP

Protein-tyrosine phosphatase 1B - ribbon model
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4ERK

Extracellular-regulated kinase 2 (ERK2) complexed with drug - ribbon model
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4Q21

H-Ras small G protein - inactive form bound to GDP - ribbon model
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Conserved Amino Acids in Catalytic Domains of Signal Transduction Proteins

These animations feature rotating 3D x-ray crystallographic structures of representative signalling proteins in complexes, which have been separately colourized to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation Title And Description

1QTN

Human Caspase 8 p18 (Residues 211-374) Human Caspase 8 p11 (Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey)
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1J4X

(Residues 211-374)
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1AS0

Rat G Protein Gi?1 (Residues 1-353)
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1CJK

(Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey)
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1UHO

Human cGMP-Specific 3,5-Cyclic Phosphodiesterase Catalytic Fragment Levitra (black) (Residues 537-860)
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1E7V

Pig Phosphatidylinositol 3-Kinase p110 Catalytic Subunit
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1BBC

Human Phospholipase A2 - IIA
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1DJX

Rat Phosphoinositide-Specific Phospholipase C-delta1 complexed with Inositol-1,4,5-trisphosphate
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1M17

Human Epidermal Growth Factor Receptor Tyrosine Kinase Catalytic Domain
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1AUI4

Human Protein-Serine Phosphatase 2B Calcineurin complexed with Calmodulin
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1G1G

Human Protein-Tyrosine Phosphatase 1B complexed with ETDYpYRKGGKGLL peptide from 1-866-kinexus TOLL FREE PHONE Insulin Receptor
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121P

Human H-Ras (Residues 1-166)
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1QTN

Human Caspase 8 p18 (Residues 211-374) Human Caspase 8 p11 (Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey)
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