Blog Comments

Kinetica Online is pleased to provide direct links to commentaries from our senior editor Dr. Steven Pelech has posted on other blogs sites. Most of these comments appear on the GenomeWeb Daily Scan website, which in turn highlight interesting blogs that have been posted at numerous sites in the blogosphere since the beginning of 2010. A wide variety of topical subjects are covered ranging from the latest scientific breakthroughs, research trends, politics and career advice. The original blogs and Dr. Pelech’s comments are summarized here under the title of the original blog. Should viewers wish to add to these discussions, they should add their comments at the original blog sites.

The views expressed by Dr. Pelech do not necessarily reflect those of the other management and staff at Kinexus Bioinformatics Corporation. However, we wish to encourage healthy debate that might spur improvements in how biomedical research is supported and conducted.

Isoform

The Proteoform

Lloyd Smith, Neil Kelleher, and the Consortium for Top Down Proteomics in a correspondence to Nature Methods suggested the term "proteoform" to describe all the shapes that a protein can assume and to differentiate it from isoforms that arise from alternative splicing of the same gene. S. Pelech suggested that if the word "proteoform" was extended to include protein complexes, the meaning of term would be too diluted and it would be overly broad. Instead, he proposed adoption of another term "proteocomplex" to refer to the specific composition and stoichiometry of subunits in protein complexes. Read More...