Microbes of Cancer
28/06/13 16:29 Filed in: GenomeWeb Daily Scan
Submitted by S. Pelech - Kinexus on Fri, 06/28/2013 - 13:58
There is no real mystery or breakthrough here. It's been known for more than 20 years that bile acids such as deoxycholic acid (DCA) and other derivatives produced by microbial action from cholic acid secreted by the liver into the gut are activators of protein kinase C (PKC) isoforms in intestinal epithelial cells amongst many other types of cells. Many of the most powerful tumour promoters described, including phorbol esters and teleocidins, also target PKC activation. Increased fat in the diet stimulates the production of bile acids and slows down the peristaltic movement of food through the intestines. While this facilitates digestion of meats, it also provides more time for bacterial actions. It is very likely that a wide range of bacteria species in the resident micro biome carry out the metabolism of bile acids into pathogenic derivatives. The simple message is to cut down on meats in your diet, and eat more vegetables and fruits.
Link to the original blog post
There is no real mystery or breakthrough here. It's been known for more than 20 years that bile acids such as deoxycholic acid (DCA) and other derivatives produced by microbial action from cholic acid secreted by the liver into the gut are activators of protein kinase C (PKC) isoforms in intestinal epithelial cells amongst many other types of cells. Many of the most powerful tumour promoters described, including phorbol esters and teleocidins, also target PKC activation. Increased fat in the diet stimulates the production of bile acids and slows down the peristaltic movement of food through the intestines. While this facilitates digestion of meats, it also provides more time for bacterial actions. It is very likely that a wide range of bacteria species in the resident micro biome carry out the metabolism of bile acids into pathogenic derivatives. The simple message is to cut down on meats in your diet, and eat more vegetables and fruits.
Link to the original blog post